“Lupe” follows Rafael, a young Cuban immigrant searching for their long-lost sister Isabel in New York City. Believing Isabel to have fallen into a life of prostitution, Rafael seeks to find and liberate her. Rafael is a trained boxer, and searching New York City’s gritty underworld often turns bloody. During a violent encounter in a brothel, Rafael comes face to face with Elsa, a woman from their shared past in rural, poverty-stricken Cuba. Pulling Elsa from her wretched environment, Rafael hopes that she can help in the search for Isabel.